› 8vgz

X-ray diffraction
2.09Å resolution

Influenza PA-N Endonuclease E23K Mutant (amino acids 52-74 truncation)

Released:
DOI: 10.2210/pdb8vgz/pdb
PDB entry 8vgz coloured by chain, front view.
PDB entry 8vgz coloured by chain, side view.
PDB entry 8vgz coloured by chain, top view.
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Primary publication:
Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.
Kohlbrand AJ, Stokes RW, Sankaran B, Cohen SM
OpenAccess logo Biochemistry 63 264-272 (2024)
PMID: 38190441

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111233 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 20.76 KDa
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C3W5S0 (Residues: 1-191; Coverage: 24%)
Gene name: PA

Ligands and Environments

1 bound ligand:
Ligand MN 2 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6222
Unit cell:
a: 75.152Å b: 75.152Å c: 120.134Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.218 0.275
Expression system: Escherichia coli BL21(DE3)

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