8vh5

Electron Microscopy
4Å resolution

Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274790 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 2527 amino acids
Theoretical weight: 286.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5S007 (Residues: 1-2527; Coverage: 100%)
Gene names: LRRK2, PARK8
Sequence domains:
Ras-related protein Rab-12 Chains: B, D
Molecule details ›
Chains: B, D
Length: 176 amino acids
Theoretical weight: 20.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IQ22 (Residues: 36-211; Coverage: 72%)
Gene name: RAB12
Sequence domains: Ras family

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-43235
Expression systems:
  • Homo sapiens
  • Escherichia coli