› 8vhw

Neutron Diffraction
2.3Å resolution

Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD

Released:
DOI: 10.2210/pdb8vhw/pdb
PDB entry 8vhw coloured by chain, front view.
PDB entry 8vhw coloured by chain, side view.
PDB entry 8vhw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Azadmanesh J, Slobodnik K, Struble LR, Lutz WE, Coates L, Weiss KL, Myles DAA, Kroll T, Borgstahl GEO
Nat Commun 15 5973 (2024)
PMID: 39013847

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 24-222; Coverage: 90%)
Gene name: SOD2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MN 2 x MN
Ligand PEO 2 x PEO
No modified residues

Experiments and Validation Details

Spacegroup: P6122
Unit cell:
a: 77.8Å b: 77.8Å c: 236.8Å α: 90° β: 90° γ: 120°
R-values:
R R work R free 0.25 0.248 0.277
Expression system: Escherichia coli

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