› 8vj4

X-ray diffraction
1.68Å resolution

X-ray Counterpart to the Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD

Released:
DOI: 10.2210/pdb8vj4/pdb
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PDB entry 8vj4 coloured by chain, front view.
PDB entry 8vj4 coloured by chain, side view.
PDB entry 8vj4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Azadmanesh J, Slobodnik K, Struble LR, Lutz WE, Coates L, Weiss KL, Myles DAA, Kroll T, Borgstahl GEO
Nat Commun 15 5973 (2024)
PMID: 39013847

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 24-222; Coverage: 90%)
Gene name: SOD2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MN 2 x MN
Ligand PEO 2 x PEO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6122
Unit cell:
a: 77.656Å b: 77.656Å c: 234.194Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.242
Expression system: Escherichia coli

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