8vjc

Electron Microscopy
3.8Å resolution

Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation.

Released:
Source organism: Homo sapiens
Primary publication:
Activation of the insulin receptor by insulin-like growth factor 2.
OpenAccess logo Nat Commun 15 2609 (2024)
PMID: 38521788
Related structures: EMD-43280

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-272041 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 1370 amino acids
Theoretical weight: 155.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06213 (Residues: 1-1382; Coverage: 99%)
  • Best match: P06213-2 (Residues: 1-1370)
Gene name: INSR
Sequence domains:
Insulin-like growth factor 2 Chains: C, D, E
Molecule details ›
Chains: C, D, E
Length: 180 amino acids
Theoretical weight: 20.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01344 (Residues: 1-180; Coverage: 100%)
Gene names: IGF-2, IGF2, PP1446
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-43280
Expression systems:
  • Homo sapiens
  • Escherichia coli