› 8vk2

X-ray diffraction
2.51Å resolution

X-ray crystal structure of human IgE 4C8 Fab

Released:
DOI: 10.2210/pdb8vk2/pdb
PDB entry 8vk2 coloured by chain, front view.
PDB entry 8vk2 coloured by chain, side view.
PDB entry 8vk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
Ball A, Khatri K, Glesner J, Vailes LD, Wünschmann S, Gabel SA, Mueller GA, Zhang J, Peebles RS, Chapman MD, Smith SA, Chruszcz M, Pomés A
J Allergy Clin Immunol (2024)
PMID: 38697404

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246134 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IgE 4C8 light chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 212 amino acids
Theoretical weight: 22.56 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
IgE 4C8 heavy chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 232 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 62.009Å b: 80.664Å c: 164.807Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.247
Expression system: Cricetulus griseus

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