› 8vkl

Electron Microscopy
2.91Å resolution

Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 2)

Released:
DOI: 10.2210/pdb8vkl/pdb
PDB entry 8vkl coloured by chain, front view.
PDB entry 8vkl coloured by chain, side view.
PDB entry 8vkl coloured by chain, top view.
Source organisms:
Entry authors: Zhu X, Mannar D, Saville J, Poloni C, Bezeruk A, Tidey K, Ahmed S, Tuttle K, Vahdatihassani F, Cholak S, Cook L, Steiner TS, Subramaniam S
Related structures: EMD-43321

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144661 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1284 amino acids
Theoretical weight: 142.23 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1207; Coverage: 94%)
Gene names: 2, S
Sequence domains:
Processed angiotensin-converting enzyme 2 Chains: D, F
Molecule details ›
Chains: D, F
Length: 621 amino acids
Theoretical weight: 71.8 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R0I0 (Residues: 1-615; Coverage: 76%)
  • Best match: Q8R0I0-2 (Residues: 1-353)
Gene name: Ace2
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 21 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.91Å
Relevant EMDB volumes: EMD-43321
Expression system: Homo sapiens

Quick links