› 8vle

Electron Microscopy
3.3Å resolution

Composite structure of human FASN with NADPH in State 1

Released:
DOI: 10.2210/pdb8vle/pdb
PDB entry 8vle coloured by chain, front view.
PDB entry 8vle coloured by chain, side view.
PDB entry 8vle coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Snapshots of acyl carrier protein shuttling in human fatty acid synthase.
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025)
PMID: 39979457
Related structures: EMD-43337

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-287880 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 2553 amino acids
Theoretical weight: 278.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand NDP 4 x NDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-43337
Expression system: Spodoptera frugiperda

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