› 8vlx

Electron Microscopy
2.6Å resolution

HTT in complex with HAP40 and a small molecule.

Released:
DOI: 10.2210/pdb8vlx/pdb
PDB entry 8vlx coloured by chain, front view.
PDB entry 8vlx coloured by chain, side view.
PDB entry 8vlx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Poweleit N, Boudet J, Doherty E
Related structures: EMD-43347

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Huntingtin Chain: A
Molecule details ›
Chain: A
Length: 3187 amino acids
Theoretical weight: 353.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42858 (Residues: 1-22, 23-3142; Coverage: 100%)
Gene names: HD, HTT, IT15
Sequence domains:
40-kDa huntingtin-associated protein Chain: B
Molecule details ›
Chain: B
Length: 389 amino acids
Theoretical weight: 41.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23610 (Residues: 1-371; Coverage: 100%)
Gene names: F8A1, F8A2, F8A3

Ligands and Environments

1 bound ligand:
Ligand A1ACS 1 x A1ACS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-43347
Expression system: Homo sapiens

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