8voj

Electron Microscopy
3.77Å resolution

The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6

Released:
Source organism: Homo sapiens
Entry authors: Xie X, Mao H, Liau B, Zheng N
Related structures: EMD-43386

Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-281851 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Kelch repeat and BTB domain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 534 amino acids
Theoretical weight: 59.97 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NVX7 (Residues: 1-534; Coverage: 100%)
Gene names: BKLHD4, KBTBD4
Sequence domains:
Histone deacetylase 1 Chain: C
Molecule details ›
Chain: C
Length: 482 amino acids
Theoretical weight: 55.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13547 (Residues: 1-482; Coverage: 100%)
Gene names: HDAC1, RPD3L1
Sequence domains: Histone deacetylase domain
REST corepressor 1 Chain: D

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.77Å
Relevant EMDB volumes: EMD-43386
Expression systems:
  • Trichoplusia ni
  • Homo sapiens