Function and Biology

CDK2-CyclinE1 in complex with allosteric inhibitor I-198.

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02984
Domain description: Cyclin, C-terminal domain
Occurring in:
  1. G1/S-specific cyclin-E1

PF00134
Domain description: Cyclin, N-terminal domain
Occurring in:
  1. G1/S-specific cyclin-E1

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 2