› 8vqb

Electron Microscopy
3Å resolution

Prefusion stabilized structure of the SARS-CoV-2 fusion machinery

Released:
DOI: 10.2210/pdb8vqb/pdb
PDB entry 8vqb coloured by chain, front view.
PDB entry 8vqb coloured by chain, side view.
PDB entry 8vqb coloured by chain, top view.
Source organism: Sarbecovirus
Primary publication:
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.
Lee J, Stewart C, Schäfer A, Leaf EM, Park YJ, Asarnow D, Powers JM, Treichel C, Sprouse KR, Corti D, Baric R, King NP, Veesler D
Nat Commun 15 5496 (2024)
PMID: 38944664
Related structures: EMD-43437

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike protein S2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 624 amino acids
Theoretical weight: 68.31 KDa
Source organism: Sarbecovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 686-1208; Coverage: 42%)
Gene names: 2, S
Sequence domains: Coronavirus spike glycoprotein S2

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-43437
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Discovery and characterization of a pan-betacoronavirus S2-binding antibody.
Johnson et al. (2024)
1 more