Function and Biology

Structure of PYCR1 complexed with NADH and N-formyl-L-proline

EC 1.5.1.2: Pyrroline-5-carboxylate reductase

Reaction catalysed:
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H
Systematic name:
L-proline:NAD(P)(+) 5-oxidoreductase
Alternative Name(s):
  • 1-pyrroline-5-carboxylate reductase
  • L-proline oxidase
  • L-proline-NAD(P)(+) 5-oxidoreductase
  • NADPH-L-Delta(1)-pyrroline carboxylic acid reductase
  • P5CR
  • Proline oxidase

Sequence families

Pfam Protein families (Pfam)
PF14748
Domain description: Pyrroline-5-carboxylate reductase dimerisation
Occurring in:
  1. Pyrroline-5-carboxylate reductase 1, mitochondrial
The deposited structure of PDB entry 8vre contains 5 copies of Pfam domain PF14748 (Pyrroline-5-carboxylate reductase dimerisation) in Pyrroline-5-carboxylate reductase 1, mitochondrial. Showing 1 copy in chain A.

PF03807
Domain description: NADP oxidoreductase coenzyme F420-dependent
Occurring in:
  1. Pyrroline-5-carboxylate reductase 1, mitochondrial
The deposited structure of PDB entry 8vre contains 5 copies of Pfam domain PF03807 (NADP oxidoreductase coenzyme F420-dependent) in Pyrroline-5-carboxylate reductase 1, mitochondrial. Showing 1 copy in chain A.