› 8vuj

Electron Microscopy
3.92Å resolution

Human GluN1-2A with Fab 003-102

Released:
DOI: 10.2210/pdb8vuj/pdb
PDB entry 8vuj coloured by chain, front view.
PDB entry 8vuj coloured by chain, side view.
PDB entry 8vuj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gómez R, Simorowski N, Vallese F, Prüss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024)
PMID: 39227719
Related structures: EMD-43531

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-274441 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 815 amino acids
Theoretical weight: 91.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 27-841; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2A Chains: B, D
Molecule details ›
Chains: B, D
Length: 808 amino acids
Theoretical weight: 90.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12879 (Residues: 34-841; Coverage: 56%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:
Glutamate receptor ionotropic, NMDA 1 Chain: C
003-102 Heavy Chains: H, I
003-102 Light Chains: L, M

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.92Å
Relevant EMDB volumes: EMD-43531
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links

Citations

1 citations in other articles

Diverse anti-NMDAR autoantibodies from individuals with encephalitis.
Jamet et al. (2024)