› 8vuq

Electron Microscopy
3.85Å resolution

Human GluN1-2A with Fab 008-218 Local refinement of ATD

Released:
DOI: 10.2210/pdb8vuq/pdb
PDB entry 8vuq coloured by chain, front view.
PDB entry 8vuq coloured by chain, side view.
PDB entry 8vuq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gómez R, Simorowski N, Vallese F, Prüss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024)
PMID: 39227719
Related structures: EMD-43536

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274444 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 369 amino acids
Theoretical weight: 41.27 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 25-393; Coverage: 40%)
Gene names: GRIN1, NMDAR1
Sequence domains: Receptor family ligand binding region
Glutamate receptor ionotropic, NMDA 2A Chain: B
Molecule details ›
Chain: B
Length: 363 amino acids
Theoretical weight: 40.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12879 (Residues: 34-396; Coverage: 25%)
Gene names: GRIN2A, NMDAR2A
Sequence domains: Receptor family ligand binding region
008-218 Heavy Chain: G
Molecule details ›
Chain: G
Length: 220 amino acids
Theoretical weight: 23.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
008-218 Light Chain: I
Molecule details ›
Chain: I
Length: 209 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.85Å
Relevant EMDB volumes: EMD-43536
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links