› 8vuu

Electron Microscopy
4.05Å resolution

Human GluN1-2B with Fab 007-168

Released:
DOI: 10.2210/pdb8vuu/pdb
PDB entry 8vuu coloured by chain, front view.
PDB entry 8vuu coloured by chain, side view.
PDB entry 8vuu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gómez R, Simorowski N, Vallese F, Prüss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024)
PMID: 39227719
Related structures: EMD-43540

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280150 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 819 amino acids
Theoretical weight: 92.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 23-838; Coverage: 89%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 815 amino acids
Theoretical weight: 91.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13224 (Residues: 31-845; Coverage: 56%)
Gene names: GRIN2B, NMDAR2B
Sequence domains:
007-168 Heavy Chains: H, J
Molecule details ›
Chains: H, J
Length: 211 amino acids
Theoretical weight: 22.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
007-168 Light Chains: K, L
Molecule details ›
Chains: K, L
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.05Å
Relevant EMDB volumes: EMD-43540
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

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