› 8vuu

Electron Microscopy
4.05Å resolution

Human GluN1-2B with Fab 007-168

Released:
DOI: 10.2210/pdb8vuu/pdb
PDB entry 8vuu coloured by chain, front view.
PDB entry 8vuu coloured by chain, side view.
PDB entry 8vuu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gómez R, Simorowski N, Vallese F, Prüss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024)
PMID: 39227719
Related structures: EMD-43540

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280150 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 819 amino acids
Theoretical weight: 92.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 815 amino acids
Theoretical weight: 91.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
007-168 Heavy Chains: H, J
007-168 Light Chains: K, L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.05Å
Relevant EMDB volumes: EMD-43540
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links

Citations

1 citations in other articles

Diverse anti-NMDAR autoantibodies from individuals with encephalitis.
Jamet et al. (2024)