› 8vyb

Electron Microscopy
3.37Å resolution

Cryo-EM structure of human core Rab3GAP1/2 complex

Released:
DOI: 10.2210/pdb8vyb/pdb
PDB entry 8vyb coloured by chain, front view.
PDB entry 8vyb coloured by chain, side view.
PDB entry 8vyb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity.
Fairlie GMJ, Nguyen KM, Nam SE, Shaw AL, Parson MAH, Shariati HR, Wang X, Jenkins ML, Gong M, Burke JE, Yip CK
Nat Commun 16 479 (2025)
PMID: 39779760
Related structures: EMD-43655

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283991 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rab3 GTPase-activating protein catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 1038 amino acids
Theoretical weight: 116.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15042 (Residues: 1-903, 904-974; Coverage: 99%)
  • Best match: Q15042-3 (Residues: 1-981)
Gene names: KIAA0066, RAB3GAP, RAB3GAP1
Sequence domains:
Rab3 GTPase-activating protein non-catalytic subunit Chain: B
Molecule details ›
Chain: B
Length: 585 amino acids
Theoretical weight: 65.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H2M9 (Residues: 1-547; Coverage: 39%)
  • Best match: Q9H2M9-2 (Residues: 1-204)
Gene names: KIAA0839, RAB3GAP2
Sequence domains: Rab3 GTPase-activating protein regulatory subunit N-terminus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.37Å
Relevant EMDB volumes: EMD-43655
Expression system: Spodoptera frugiperda

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