› 8vzp

X-ray diffraction
1.72Å resolution

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-403

Released:
DOI: 10.2210/pdb8vzp/pdb
PDB entry 8vzp coloured by chain, front view.
PDB entry 8vzp coloured by chain, side view.
PDB entry 8vzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu.
Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW
Proc Natl Acad Sci U S A 121 e2321344121 (2024)
PMID: 38830107

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 242 amino acids
Theoretical weight: 27.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 305-546; Coverage: 41%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand A1AHW 4 x A1AHW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 53.558Å b: 58.906Å c: 93.244Å
α: 86.76° β: 74.95° γ: 63.05°
R-values:
R R work R free
0.183 0.181 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links