› 8w32

X-ray diffraction
1.72Å resolution

Structure and interactions of HIV-1 gp41 CHR-NHR reverse hairpin constructs reveal molecular determinants of antiviral activity

Released:
DOI: 10.2210/pdb8w32/pdb
Model geometry
Fit model/data
PDB entry 8w32 coloured by chain, front view.
PDB entry 8w32 coloured by chain, side view.
PDB entry 8w32 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity.
He L, McAndrew R, Barbu R, Gifford G, Halacoglu C, Drouin-Allaire C, Weber L, Kristensen LG, Gupta S, Chen Y, Petzold CJ, Allaire M, Li KH, Ralston CY, Gochin M
J Mol Biol 436 168650 (2024)
PMID: 38866091

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.72 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 542-591; Coverage: 6%)
Gene name: env

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: R32
Unit cell:
a: 45.057Å b: 45.057Å c: 219.846Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.253 0.29
Expression system: Escherichia coli

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