› 8w9w

Electron Microscopy
3.74Å resolution

The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine

Released:
DOI: 10.2210/pdb8w9w/pdb
PDB entry 8w9w coloured by chain, front view.
PDB entry 8w9w coloured by chain, side view.
PDB entry 8w9w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024)
PMID: 38388831
Related structures: EMD-37383

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingomyelin synthase-related protein 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 264 amino acids
Theoretical weight: 31.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96LT4 (Residues: 144-407; Coverage: 64%)
Gene name: SAMD8
Sequence domains: PAP2 superfamily C-terminal

Ligands and Environments

2 bound ligands:
Ligand UJO 6 x UJO
Ligand OPE 4 x OPE
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.74Å
Relevant EMDB volumes: EMD-37383
Expression system: Homo sapiens

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