Cryo-EM structure of peptide free and Gs-coupled GIPR
Source organisms:
Biochemical function:
protein binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: plasma membrane
Biological process: G protein-coupled receptor signaling pathway
Cellular component: plasma membrane
Protein families (Pfam)![The deposited structure of PDB entry 8wa3 contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/8wa3_3_B_Pfam_PF00400_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8wa3</span> contains 7 copies of Pfam domain <span class='highlight'>PF00400 (WD domain, G-beta repeat)</span> in <span class='highlight'>Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1</span>. Showing 7 copies in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 8wa3 contains 1 copy of Pfam domain PF00002 (7 transmembrane receptor (Secretin family)) in Gastric inhibitory polypeptide receptor. Showing 1 copy in chain A [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/8wa3_1_R_Pfam_PF00002_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8wa3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00002 (7 transmembrane receptor (Secretin family))</span> in <span class='highlight'>Gastric inhibitory polypeptide receptor</span>. Showing 1 copy in chain <span class='highlight'>A [auth R]</span>.")
![The deposited structure of PDB entry 8wa3 contains 1 copy of Pfam domain PF02793 (Hormone receptor domain) in Gastric inhibitory polypeptide receptor. Showing 1 copy in chain A [auth R] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/8wa3_1_R_Pfam_PF02793_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8wa3</span> contains 1 copy of Pfam domain <span class='highlight'>PF02793 (Hormone receptor domain)</span> in <span class='highlight'>Gastric inhibitory polypeptide receptor</span>. Showing 1 copy in chain <span class='highlight'>A [auth R]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 8wa3 contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain D [auth G].](https://www.ebi.ac.uk/pdbe/static/entry/8wa3_4_G_Pfam_PF00631_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8wa3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00631 (GGL domain)</span> in <span class='highlight'>Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2</span>. Showing 1 copy in chain <span class='highlight'>D [auth G]</span>.")
![The deposited structure of PDB entry 8wa3 contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/8wa3_2_A_Pfam_PF00503_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8wa3</span> contains 1 copy of Pfam domain <span class='highlight'>PF00503 (G-protein alpha subunit)</span> in <span class='highlight'>Guanine nucleotide-binding protein G(s) subunit alpha isoforms short</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")