Function and Biology Details
Reactions catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
ATP + a protein = ADP + a phosphoprotein
ATP + H(2)O = ADP + phosphate
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 51-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236181 (preferred)
Entry contents:
42 distinct polypeptide molecules
2 distinct DNA molecules
1 distinct RNA molecule
2 distinct DNA molecules
1 distinct RNA molecule
Macromolecules (45 distinct):
CDK-activating kinase assembly factor MAT1
Chain: 0
Molecule details ›
General transcription factor IIH subunit 1
Chain: 1
Molecule details ›
Chain: 1
Length: 548 amino acids
Theoretical weight: 62.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 548 amino acids
Theoretical weight: 62.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P32780 (Residues: 1-548; Coverage: 100%)
Sequence domains:
General transcription factor IIH subunit 2
Chain: 2
Molecule details ›
Chain: 2
Length: 395 amino acids
Theoretical weight: 44.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 395 amino acids
Theoretical weight: 44.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q13888 (Residues: 1-395; Coverage: 100%)
Sequence domains:
General transcription factor IIH subunit 3
Chain: 3
Molecule details ›
Chain: 3
Length: 308 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription factor Tfb4
Length: 308 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q13889 (Residues: 1-308; Coverage: 100%)
Sequence domains: Transcription factor Tfb4
General transcription factor IIH subunit 4
Chain: 4
Molecule details ›
Chain: 4
Length: 462 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 462 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q92759 (Residues: 1-462; Coverage: 100%)
Sequence domains:
General transcription factor IIH subunit 5
Chain: 5
Molecule details ›
Chain: 5
Length: 71 amino acids
Theoretical weight: 8.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription factor TFIIH complex subunit Tfb5
Length: 71 amino acids
Theoretical weight: 8.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q6ZYL4 (Residues: 1-71; Coverage: 100%)
Sequence domains: Transcription factor TFIIH complex subunit Tfb5
General transcription and DNA repair factor IIH helicase/translocase subunit XPB
Chain: 6
Molecule details ›
Chain: 6
Length: 782 amino acids
Theoretical weight: 89.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 782 amino acids
Theoretical weight: 89.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P19447 (Residues: 1-782; Coverage: 100%)
Sequence domains:
General transcription and DNA repair factor IIH helicase subunit XPD
Chain: 7
Molecule details ›
Chain: 7
Length: 760 amino acids
Theoretical weight: 87.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 760 amino acids
Theoretical weight: 87.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P18074 (Residues: 1-760; Coverage: 100%)
Sequence domains:
Alpha-amanitin
Chain: N
Molecule details ›
Chain: N
Length: 8 amino acids
Theoretical weight: 939 Da
Source organism: Amanita phalloides
UniProt:
Length: 8 amino acids
Theoretical weight: 939 Da
Source organism: Amanita phalloides
UniProt:
- Canonical: P85421 (Residues: 1-8; Coverage: 35%)
Transcription initiation factor TFIID subunit 1
Chain: A
Molecule details ›
Transcription initiation factor TFIID subunit 2
Chain: B
Molecule details ›
Chain: B
Length: 1199 amino acids
Theoretical weight: 137.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Length: 1199 amino acids
Theoretical weight: 137.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q6P1X5 (Residues: 1-1199; Coverage: 100%)
Transcription initiation factor TFIID subunit 4
Chains: D, d
Molecule details ›
Transcription initiation factor TFIID subunit 5
Chains: E, e
Molecule details ›
Chains: E, e
Length: 800 amino acids
Theoretical weight: 86.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 800 amino acids
Theoretical weight: 86.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q15542 (Residues: 1-800; Coverage: 100%)
Sequence domains:
Transcription initiation factor TFIID subunit 6
Chains: F, f
Molecule details ›
Chains: F, f
Length: 677 amino acids
Theoretical weight: 72.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 677 amino acids
Theoretical weight: 72.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P49848 (Residues: 1-677; Coverage: 100%)
Sequence domains:
Transcription initiation factor TFIID subunit 7
Chain: G
Molecule details ›
Chain: G
Length: 349 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: TAFII55 protein conserved region
Length: 349 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q15545 (Residues: 1-349; Coverage: 100%)
Sequence domains: TAFII55 protein conserved region
Transcription initiation factor TFIID subunit 8
Chain: H
Molecule details ›
Chain: H
Length: 310 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 310 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q7Z7C8 (Residues: 1-310; Coverage: 100%)
Sequence domains:
Transcription initiation factor TFIID subunit 9
Chains: I, i
Molecule details ›
Chains: I, i
Length: 264 amino acids
Theoretical weight: 29.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription initiation factor IID, 31kD subunit
Length: 264 amino acids
Theoretical weight: 29.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q16594 (Residues: 1-264; Coverage: 100%)
Sequence domains: Transcription initiation factor IID, 31kD subunit
Transcription initiation factor TFIID subunit 10
Chains: J, j
Molecule details ›
Chains: J, j
Length: 218 amino acids
Theoretical weight: 21.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription initiation factor TFIID 23-30kDa subunit
Length: 218 amino acids
Theoretical weight: 21.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q12962 (Residues: 1-218; Coverage: 100%)
Sequence domains: Transcription initiation factor TFIID 23-30kDa subunit
Transcription initiation factor TFIID subunit 12
Chains: L, l
Molecule details ›
Chains: L, l
Length: 161 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription initiation factor TFIID subunit A
Length: 161 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q16514 (Residues: 1-161; Coverage: 100%)
Sequence domains: Transcription initiation factor TFIID subunit A
Transcription initiation factor IIA subunit 2
Chain: O
Molecule details ›
Chain: O
Length: 109 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 109 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P52657 (Residues: 1-109; Coverage: 100%)
Sequence domains:
TATA-box-binding protein
Chain: P
Molecule details ›
Chain: P
Length: 339 amino acids
Theoretical weight: 37.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription factor TFIID (or TATA-binding protein, TBP)
Length: 339 amino acids
Theoretical weight: 37.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P20226 (Residues: 1-339; Coverage: 100%)
Sequence domains: Transcription factor TFIID (or TATA-binding protein, TBP)
Transcription initiation factor IIA subunit 1
Chain: Q
Molecule details ›
Chain: Q
Length: 376 amino acids
Theoretical weight: 41.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription factor IIA, alpha/beta subunit
Length: 376 amino acids
Theoretical weight: 41.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P52655 (Residues: 1-376; Coverage: 100%)
Sequence domains: Transcription factor IIA, alpha/beta subunit
Transcription initiation factor IIB
Chain: R
Molecule details ›
Chain: R
Length: 316 amino acids
Theoretical weight: 34.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 316 amino acids
Theoretical weight: 34.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q00403 (Residues: 1-316; Coverage: 100%)
Sequence domains:
General transcription factor IIF subunit 1
Chain: S
Molecule details ›
Chain: S
Length: 517 amino acids
Theoretical weight: 58.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
Length: 517 amino acids
Theoretical weight: 58.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P35269 (Residues: 1-517; Coverage: 100%)
Sequence domains: Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
General transcription factor IIF subunit 2
Chain: T
Molecule details ›
Chain: T
Length: 249 amino acids
Theoretical weight: 28.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 249 amino acids
Theoretical weight: 28.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P13984 (Residues: 1-249; Coverage: 100%)
Sequence domains:
General transcription factor IIE subunit 1
Chain: U
Molecule details ›
Chain: U
Length: 439 amino acids
Theoretical weight: 49.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 439 amino acids
Theoretical weight: 49.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P29083 (Residues: 1-439; Coverage: 100%)
Sequence domains:
Transcription initiation factor IIE subunit beta
Chain: V
Molecule details ›
Chain: V
Length: 291 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 291 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P29084 (Residues: 1-291; Coverage: 100%)
Sequence domains:
Transcription initiation factor TFIID subunit 3
Chain: c
Molecule details ›
Chain: c
Length: 929 amino acids
Theoretical weight: 103.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 929 amino acids
Theoretical weight: 103.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q5VWG9 (Residues: 1-929; Coverage: 100%)
Sequence domains:
Transcription initiation factor TFIID subunit 11
Chain: k
Molecule details ›
Chain: k
Length: 211 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: hTAFII28-like protein conserved region
Length: 211 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q15544 (Residues: 1-211; Coverage: 100%)
Sequence domains: hTAFII28-like protein conserved region
Transcription initiation factor TFIID subunit 13
Chain: m
Molecule details ›
Chain: m
Length: 124 amino acids
Theoretical weight: 14.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Transcription initiation factor IID, 18kD subunit
Length: 124 amino acids
Theoretical weight: 14.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q15543 (Residues: 1-124; Coverage: 100%)
Sequence domains: Transcription initiation factor IID, 18kD subunit
DNA-directed RNA polymerase subunit
Chain: o
Molecule details ›
Chain: o
Length: 1970 amino acids
Theoretical weight: 217.45 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 1970 amino acids
Theoretical weight: 217.45 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A8D1DPV6 (Residues: 1-1970; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit beta
Chain: p
Molecule details ›
Chain: p
Length: 1174 amino acids
Theoretical weight: 134.04 KDa
Source organism: Sus scrofa
UniProt:
Length: 1174 amino acids
Theoretical weight: 134.04 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A4X1TVZ5 (Residues: 78-1251; Coverage: 94%)
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
Chain: q
Molecule details ›
Chain: q
Length: 275 amino acids
Theoretical weight: 31.44 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 275 amino acids
Theoretical weight: 31.44 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: I3LCH3 (Residues: 1-275; Coverage: 100%)
Sequence domains:
RNA polymerase Rpb4/RPC9 core domain-containing protein
Chain: r
Molecule details ›
Chain: r
Length: 142 amino acids
Theoretical weight: 16.33 KDa
Source organism: Sus scrofa
UniProt:
Length: 142 amino acids
Theoretical weight: 16.33 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A481BYI6 (Residues: 1-142; Coverage: 100%)
DNA-directed RNA polymerase II subunit E
Chain: s
Molecule details ›
Chain: s
Length: 210 amino acids
Theoretical weight: 24.64 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 210 amino acids
Theoretical weight: 24.64 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A4X1VTX4 (Residues: 1-210; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Chain: t
Molecule details ›
Chain: t
Length: 127 amino acids
Theoretical weight: 14.48 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb6
Length: 127 amino acids
Theoretical weight: 14.48 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A4X1VEK9 (Residues: 1-127; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
DNA-directed RNA polymerase subunit
Chain: u
Molecule details ›
Chain: u
Length: 172 amino acids
Theoretical weight: 19.31 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 172 amino acids
Theoretical weight: 19.31 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A4X1VKG7 (Residues: 1-172; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Chain: v
Molecule details ›
Chain: v
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb8
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: I3LCB2 (Residues: 1-150; Coverage: 100%)
Sequence domains: RNA polymerase Rpb8
DNA-directed RNA polymerase II subunit RPB9
Chain: w
Molecule details ›
Chain: w
Length: 125 amino acids
Theoretical weight: 14.54 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 125 amino acids
Theoretical weight: 14.54 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: P60899 (Residues: 1-125; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Chain: x
Molecule details ›
Chain: x
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerases N / 8 kDa subunit
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A493TD97 (Residues: 1-67; Coverage: 100%)
Sequence domains: RNA polymerases N / 8 kDa subunit
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
Chain: y
Molecule details ›
Chain: y
Length: 117 amino acids
Theoretical weight: 13.31 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
Length: 117 amino acids
Theoretical weight: 13.31 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: F1RKE4 (Residues: 1-117; Coverage: 100%)
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
RNA polymerase II, I and III subunit K
Chain: z
Molecule details ›
Chain: z
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Sus scrofa
UniProt:
- Canonical: A0A4X1TRS6 (Residues: 1-58; Coverage: 100%)
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
non-template DNA
Chain: X
Molecule details ›
Chain: X
Length: 99 nucleotides
Theoretical weight: 30.63 KDa
Length: 99 nucleotides
Theoretical weight: 30.63 KDa
template DNA
Chain: Y
Molecule details ›
Chain: Y
Length: 99 nucleotides
Theoretical weight: 30.46 KDa
Length: 99 nucleotides
Theoretical weight: 30.46 KDa
RNA
Chain: Z
Molecule details ›
Chain: Z
Length: 6 nucleotides
Theoretical weight: 2.12 KDa
Length: 6 nucleotides
Theoretical weight: 2.12 KDa