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Cryo-EM structure of ACE2-B0AT1 complex with JX98

Source organism: Homo sapiens
Biochemical function: peptidyl-dipeptidase activity
Biological process: proteolysis
Cellular component: membrane

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EC 3.4.17.23: Angiotensin-converting enzyme 2

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Systematic name:
-
Alternative Name(s):
  • ACE-2
  • ACE2
  • Angiotensin converting enzyme 2
  • Angiotensin converting enzyme-2
  • HACE2
  • Tmem27

GO terms

Sequence families

Pfam Protein families (Pfam)
PF16959
Domain description: Renal amino acid transporter
Occurring in:
  1. Angiotensin-converting enzyme 2
The deposited structure of PDB entry 8wby contains 2 copies of Pfam domain PF16959 (Renal amino acid transporter) in Angiotensin-converting enzyme 2. Showing 1 copy in chain B.

PF01401
Domain description: Angiotensin-converting enzyme
Occurring in:
  1. Angiotensin-converting enzyme 2
The deposited structure of PDB entry 8wby contains 2 copies of Pfam domain PF01401 (Angiotensin-converting enzyme) in Angiotensin-converting enzyme 2. Showing 1 copy in chain B.

PF00209
Domain description: Sodium:neurotransmitter symporter family
Occurring in:
  1. Sodium-dependent neutral amino acid transporter B(0)AT1
The deposited structure of PDB entry 8wby contains 2 copies of Pfam domain PF00209 (Sodium:neurotransmitter symporter family) in Sodium-dependent neutral amino acid transporter B(0)AT1. Showing 1 copy in chain A.

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