› 8wfk

Electron Microscopy
3.22Å resolution

human glycine transporter 1 in complex with SSR504734 in outward facing conformation

Released:
DOI: 10.2210/pdb8wfk/pdb
PDB entry 8wfk coloured by chain, front view.
PDB entry 8wfk coloured by chain, side view.
PDB entry 8wfk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transport mechanism and pharmacology of the human GlyT1.
Wei Y, Li R, Meng Y, Hu T, Zhao J, Gao Y, Bai Q, Li N, Zhao Y
Cell (2024)
PMID: 38513663
Related structures: EMD-37494

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium- and chloride-dependent glycine transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 652 amino acids
Theoretical weight: 72.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48067 (Residues: 1-706; Coverage: 92%)
Gene name: SLC6A9
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

3 bound ligands:
Ligand W5O 1 x W5O
Ligand CL 1 x CL
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.22Å
Relevant EMDB volumes: EMD-37494
Expression system: Homo sapiens

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