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Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc.

Electron Microscopy
3.47Å resolution
PDB entry 8wgx coloured by chain, front view.
PDB entry 8wgx coloured by chain, side view.
PDB entry 8wgx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sodium-dependent noradrenaline transporter
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Multimeric state: monomeric
Accessible surface area: 22288.14 Å2
Buried surface area: 876.83 Å2
Dissociation area: 210.38 Å2
Dissociation energy (ΔGdiss): -2.48 kcal/mol
Dissociation entropy (TΔSdiss): 2.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-273409

Macromolecules

Sodium-dependent noradrenaline transporter
Chain: A
Length: 617 amino acids
Theoretical weight: 69.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23975 (Residues: 1-617; Coverage: 100%)
Gene names: NAT1, NET1, SLC6A2, SLC6A5
Pfam: Sodium:neurotransmitter symporter family
Sodium-dependent noradrenaline transporter in PDB entry 8wgx, assembly 1, front view.
Sodium-dependent noradrenaline transporter in PDB entry 8wgx, assembly 1, side view.
Sodium-dependent noradrenaline transporter in PDB entry 8wgx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P23975  
161750100150200250300350400450500550600
 
200400600MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
UniProt
P23975
Chains
Secondary structure
Flexibility predictions
Ligand binding sites
Sequence conservation
Molecule details ›

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