› 8whs

Electron Microscopy
3.33Å resolution

Spike Trimer of BA.2.86 in complex with one hACE2

Released:
DOI: 10.2210/pdb8whs/pdb
PDB entry 8whs coloured by chain, front view.
PDB entry 8whs coloured by chain, side view.
PDB entry 8whs coloured by chain, top view.
Source organisms:
Primary publication:
Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev 11 nwae206 (2024)
PMID: 39071099
Related structures: EMD-37546

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144662 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1206 amino acids
Theoretical weight: 134.04 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 28-1208; Coverage: 93%)
Gene names: 2, S
Sequence domains:
Processed angiotensin-converting enzyme 2 Chain: D
Molecule details ›
Chain: D
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 19-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand NAG 35 x NAG
Ligand ZN 1 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.33Å
Relevant EMDB volumes: EMD-37546
Expression system: Homo sapiens

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