› 8wi2

Electron Microscopy
4.06Å resolution

RD-hMRP5-inward open

Released:
DOI: 10.2210/pdb8wi2/pdb
PDB entry 8wi2 coloured by chain, front view.
PDB entry 8wi2 coloured by chain, side view.
PDB entry 8wi2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition and transport mechanisms of the ABC transporter hMRP5.
Huang Y, Xue C, Bu R, Wu C, Li J, Zhang J, Chen J, Shi Z, Chen Y, Wang Y, Liu Z
Nat Commun 15 4811 (2024)
PMID: 38844452
Related structures: EMD-37555

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246577 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-binding cassette sub-family C member 5 Chain: A
Molecule details ›
Chain: A
Length: 1334 amino acids
Theoretical weight: 149.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15440 (Residues: 94-1427; Coverage: 93%)
Gene names: ABCC5, MRP5
Sequence domains:
ATP-binding cassette sub-family C member 5 Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 1.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15440 (Residues: 46-64; Coverage: 1%)
Gene names: ABCC5, MRP5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.06Å
Relevant EMDB volumes: EMD-37555
Expression system: Homo sapiens

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