› 8wj0

Electron Microscopy
2.24Å resolution

cryo-EM structure of human haemoglobin in carbonmonoxy form

Released:
DOI: 10.2210/pdb8wj0/pdb
PDB entry 8wj0 coloured by chain, front view.
PDB entry 8wj0 coloured by chain, side view.
PDB entry 8wj0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM.
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun 15 6505 (2024)
PMID: 39090102
Related structures: EMD-37574

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250294 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 15.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 1-142; Coverage: 100%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Hemoglobin subunit beta Chain: B
Molecule details ›
Chain: B
Length: 147 amino acids
Theoretical weight: 16.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 1-147; Coverage: 100%)
Gene name: HBB
Sequence domains: Globin

Ligands and Environments

2 bound ligands:
Ligand HEM 2 x HEM
Ligand CMO 2 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.24Å
Relevant EMDB volumes: EMD-37574

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