› 8wlz

Electron Microscopy
4.45Å resolution

Cryo-EM structure of the WIV1 S-hACE2 complex

Released:
DOI: 10.2210/pdb8wlz/pdb
PDB entry 8wlz coloured by chain, front view.
PDB entry 8wlz coloured by chain, side view.
PDB entry 8wlz coloured by chain, top view.
Source organisms:
Primary publication:
Structural determinants of spike infectivity in bat SARS-like coronaviruses RsSHC014 and WIV1.
Qiao S, Wang X
J Virol e0034224 (2024)
PMID: 39028202
Related structures: EMD-37636

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-247072 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Fibritin C-terminal domain-containing protein; Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1271 amino acids
Theoretical weight: 140.75 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: U5WLK5 (Residues: 1-1191; Coverage: 95%)
  • Canonical: A0A346FJN8 (Residues: 458-483; Coverage: 5%)
Gene names: EcT6_00157, S, wac
Sequence domains:
Processed angiotensin-converting enzyme 2 Chains: D, G
Molecule details ›
Chains: D, G
Length: 603 amino acids
Theoretical weight: 69.98 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9BYF1 (Residues: 19-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 21 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.45Å
Relevant EMDB volumes: EMD-37636
Expression systems:
  • Homo sapiens
  • Trichoplusia ni

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