› 8wma

Electron Microscopy
3.47Å resolution

Fzd4/DEP complex (local refined)

Released:
DOI: 10.2210/pdb8wma/pdb
PDB entry 8wma coloured by chain, front view.
PDB entry 8wma coloured by chain, side view.
PDB entry 8wma coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.
Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y
Nat Commun 15 7644 (2024)
PMID: 39223191
Related structures: EMD-37647

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-251257 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Frizzled-4 Chain: A
Molecule details ›
Chain: A
Length: 537 amino acids
Theoretical weight: 60.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9ULV1 (Residues: 1-537; Coverage: 100%)
Gene name: FZD4
Sequence domains:
Segment polarity protein dishevelled homolog DVL-2 Chain: C
Molecule details ›
Chain: C
Length: 736 amino acids
Theoretical weight: 79.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14641 (Residues: 1-736; Coverage: 100%)
Gene name: DVL2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.47Å
Relevant EMDB volumes: EMD-37647
Expression system: Spodoptera frugiperda

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