8wny

Electron Microscopy
3.5Å resolution

Cryo EM map of SLC7A10-SLC3A2 complex in the D-serine bound state

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human Asc-1 transporter complex.
OpenAccess logo Nat Commun 15 3036 (2024)
PMID: 38589439
Related structures: EMD-37675

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-272412 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amino acid transporter heavy chain SLC3A2 Chain: A
Molecule details ›
Chain: A
Length: 631 amino acids
Theoretical weight: 68.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08195 (Residues: 1-67, 68-630; Coverage: 100%)
  • Best match: P08195-5 (Residues: 1-631)
Gene names: MDU1, SLC3A2
Sequence domains:
Asc-type amino acid transporter 1 Chain: B
Molecule details ›
Chain: B
Length: 523 amino acids
Theoretical weight: 56.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NS82 (Residues: 1-523; Coverage: 100%)
Gene names: ASC1, SLC7A10
Sequence domains: Amino acid permease

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-37675
Expression system: Homo sapiens