› 8wog

Electron Microscopy
2.97Å resolution

Cryo-EM structure of SUCR1 in complex with succinate and Gi protein

Released:
DOI: 10.2210/pdb8wog/pdb
PDB entry 8wog coloured by chain, front view.
PDB entry 8wog coloured by chain, side view.
PDB entry 8wog coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into ligand recognition and activation of the succinate receptor SUCNR1.
Liu A, Liu Y, Zhang W, Ye RD
Cell Rep 43 114381 (2024)
PMID: 38923454
Related structures: EMD-37686

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-273996 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Succinate receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 35.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXA5 (Residues: 8-318; Coverage: 93%)
Gene names: GPR91, SUCNR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 353 amino acids
Theoretical weight: 40.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 2-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: D
Molecule details ›
Chain: D
Length: 338 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 3-340; Coverage: 99%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: E
Molecule details ›
Chain: E
Length: 56 amino acids
Theoretical weight: 6.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 8-63; Coverage: 79%)
Gene name: GNG2
Sequence domains: GGL domain

Ligands and Environments

1 bound ligand:
Ligand SIN 1 x SIN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.97Å
Relevant EMDB volumes: EMD-37686
Expression system: Spodoptera frugiperda

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