› 8wp8

Electron Microscopy
2.89Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2

Released:
DOI: 10.2210/pdb8wp8/pdb
PDB entry 8wp8 coloured by chain, front view.
PDB entry 8wp8 coloured by chain, side view.
PDB entry 8wp8 coloured by chain, top view.
Source organisms:
Entry authors: Li LJ, Gu YH, Qi JX, Gao GF
Related structures: EMD-37711

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 606 amino acids
Theoretical weight: 70.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 18-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 228 amino acids
Theoretical weight: 26.12 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand ZN 1 x ZN
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-37711
Expression system: Homo sapiens

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