› 8wpl

Electron Microscopy
3.04Å resolution

Cryo-EM structure of the human TRPC1/C4 heteromer

Released:
DOI: 10.2210/pdb8wpl/pdb
PDB entry 8wpl coloured by chain, front view.
PDB entry 8wpl coloured by chain, side view.
PDB entry 8wpl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel.
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024)
PMID: 39478185
Related structures: EMD-37718

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-281613 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Short transient receptor potential channel 1 Chain: A
Molecule details ›
Chain: A
Length: 797 amino acids
Theoretical weight: 91.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48995 (Residues: 1-793; Coverage: 100%)
Gene names: TRP1, TRPC1
Sequence domains:
Short transient receptor potential channel 4 Chains: B, C, D
Molecule details ›
Chains: B, C, D
Length: 915 amino acids
Theoretical weight: 105.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UBN4 (Residues: 1-977; Coverage: 91%)
  • Best match: Q9UBN4-2 (Residues: 1-893)
Gene name: TRPC4
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand LPP 4 x LPP
Ligand ZN 4 x ZN
Ligand Y01 3 x Y01
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.04Å
Relevant EMDB volumes: EMD-37718
Expression system: Homo sapiens

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