› 8wqi

Electron Microscopy
3.5Å resolution

Local refinement of FEM1B bound with the C-degron of CUX1

Released:
DOI: 10.2210/pdb8wqi/pdb
PDB entry 8wqi coloured by chain, front view.
PDB entry 8wqi coloured by chain, side view.
PDB entry 8wqi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase.
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
OpenAccess logo Nat Commun 15 3558 (2024)
PMID: 38670995
Related structures: EMD-37746

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242668 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein fem-1 homolog B Chain: D
Molecule details ›
Chain: D
Length: 627 amino acids
Theoretical weight: 70.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UK73 (Residues: 1-627; Coverage: 100%)
Gene names: F1AA, FEM1B, KIAA0396
Sequence domains: Ankyrin repeats (3 copies)
Protein CASP Chain: G
Molecule details ›
Chain: G
Length: 31 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13948 (Residues: 656-678; Coverage: 3%)
Gene names: CUTL1, CUX1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-37746
Expression system: Escherichia coli

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