› 8wtu

Electron Microscopy
2.7Å resolution

Cryo-EM structure of noradrenaline transporter in apo state

Released:
DOI: 10.2210/pdb8wtu/pdb
PDB 8wtu front image not found
PDB 8wtu side image not found
PDB 8wtu top image not found
Source organism: Homo sapiens
Primary publication:
Transport and inhibition mechanisms of the human noradrenaline transporter.
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024)
Related structures: EMD-37842

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent noradrenaline transporter Chain: A
Molecule details ›
Chain: A
Length: 566 amino acids
Theoretical weight: 63.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23975 (Residues: 52-617; Coverage: 92%)
Gene names: NAT1, NET1, SLC6A2, SLC6A5
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-37842
Expression system: Homo sapiens

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