› 8wx4

Electron Microscopy
3.12Å resolution

Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)

Released:
DOI: 10.2210/pdb8wx4/pdb
PDB entry 8wx4 coloured by chain, front view.
PDB entry 8wx4 coloured by chain, side view.
PDB entry 8wx4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sakaniwa K, Zhang Z, Ohto U, Shimizu T
Related structures: EMD-37900

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230386 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 15 member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 600 amino acids
Theoretical weight: 64.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N697 (Residues: 1-577; Coverage: 100%)
Gene names: FP12591, PHT1, PTR4, SLC15A4
Sequence domains: POT family

Ligands and Environments

2 bound ligands:
Ligand LYS 2 x LYS
Ligand LEU 2 x LEU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-37900
Expression system: Homo sapiens

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