› 8wx5

Electron Microscopy
3.91Å resolution

Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)

Released:
DOI: 10.2210/pdb8wx5/pdb
PDB entry 8wx5 coloured by chain, front view.
PDB entry 8wx5 coloured by chain, side view.
PDB entry 8wx5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ohto U, Zhang Z, Fujimura A, Shimizu T
Related structures: EMD-37901

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230385 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Solute carrier family 15 member 4 Chain: A
Molecule details ›
Chain: A
Length: 600 amino acids
Theoretical weight: 64.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N697 (Residues: 1-577; Coverage: 100%)
Gene names: FP12591, PHT1, PTR4, SLC15A4
Sequence domains: POT family
TLR adapter interacting with SLC15A4 on the lysosome Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HAI6 (Residues: 1-15; Coverage: 5%)
Gene names: CXorf21, TASL

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.91Å
Relevant EMDB volumes: EMD-37901
Expression system: Homo sapiens

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