› 8wxr

X-ray diffraction
2.08Å resolution

Structure of WDR5 in complex with WIN motif containing MBD3C F47A

Released:
DOI: 10.2210/pdb8wxr/pdb
PDB entry 8wxr coloured by chain, front view.
PDB entry 8wxr coloured by chain, side view.
PDB entry 8wxr coloured by chain, top view.
Source organisms:
Primary publication:
Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode.
Yang Y, Xu L, Zhang S, Yao L, Ding Y, Li W, Chen X
J Biol Chem 107468 (2024)
PMID: 38876301

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-548825 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 34.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
MBD3C Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.17 KDa
Source organism: Mus musculus
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 64.697Å b: 47.028Å c: 103.05Å
α: 90° β: 107.47° γ: 90°
R-values:
R R work R free
0.157 0.153 0.199
Expression system: Escherichia coli

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