› 8wxt

X-ray diffraction
1.83Å resolution

Structure of WDR5 in complex with WIN motif containing MBD3C R45E/V46G

Released:
DOI: 10.2210/pdb8wxt/pdb
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PDB entry 8wxt coloured by chain, front view.
PDB entry 8wxt coloured by chain, side view.
PDB entry 8wxt coloured by chain, top view.
Source organisms:
Primary publication:
Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode.
Yang Y, Xu L, Zhang S, Yao L, Ding Y, Li W, Chen X
J Biol Chem 107468 (2024)
PMID: 38876301

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274066 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 34.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
MBD3C Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2221
Unit cell:
a: 78.442Å b: 98.831Å c: 80.178Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.151 0.179
Expression system: Escherichia coli

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