› 8wz2

Electron Microscopy
2.73Å resolution

Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex

Released:
DOI: 10.2210/pdb8wz2/pdb
PDB entry 8wz2 coloured by chain, front view.
PDB entry 8wz2 coloured by chain, side view.
PDB entry 8wz2 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
OpenAccess logo Cell Discov 10 58 (2024)
PMID: 38830850
Related structures: EMD-37944

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-246059 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
G-alpha q Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.72 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54311 (Residues: 1-340; Coverage: 100%)
Gene name: Gnb1
Sequence domains: WD domain, G-beta repeat
scFV16 Chain: E
Molecule details ›
Chain: E
Length: 247 amino acids
Theoretical weight: 26.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63212 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
QRF-amide Chain: L
Molecule details ›
Chain: L
Length: 27 amino acids
Theoretical weight: 2.88 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8CE23 (Residues: 97-123; Coverage: 25%)
Gene name: Qrfp
Pyroglutamylated RF-amide peptide receptor Chain: R
Molecule details ›
Chain: R
Length: 431 amino acids
Theoretical weight: 49.55 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96P65 (Residues: 1-431; Coverage: 100%)
Gene names: GPR103, QRFPR
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.73Å
Relevant EMDB volumes: EMD-37944
Expression system: Trichoplusia ni

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