› 8x0h

Electron Microscopy
4.1Å resolution

Human FL Metabotropic glutamate receptor 5, mGlu5-5M with quisqualate, Rcc conformation

Released:
DOI: 10.2210/pdb8x0h/pdb
PDB entry 8x0h coloured by chain, front view.
PDB entry 8x0h coloured by chain, side view.
PDB entry 8x0h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational diversity in class C GPCR positive allosteric modulation.
Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G
Nat Commun 16 619 (2025)
PMID: 39805839
Related structures: EMD-37979

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 836 amino acids
Theoretical weight: 93.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P41594 (Residues: 21-856; Coverage: 70%)
Gene names: GPRC1E, GRM5, MGLUR5
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand QUS 2 x QUS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-37979
Expression system: Homo sapiens

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