› 8x0s

X-ray diffraction
2.96Å resolution

Crystal structure of r(G4C2)2

Released:
DOI: 10.2210/pdb8x0s/pdb
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PDB entry 8x0s coloured by chain, front view.
PDB entry 8x0s coloured by chain, side view.
PDB entry 8x0s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD.
Geng Y, Liu C, Xu N, Suen MC, Miao H, Xie Y, Zhang B, Chen X, Song Y, Wang Z, Cai Q, Zhu G
Nucleic Acids Res (2024)
PMID: 38860430

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246130 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand K 9 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6122
Unit cell:
a: 62.971Å b: 62.971Å c: 129.227Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.263 0.261 0.3
Expression system: Not provided

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