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Structure of nucleosome-bound SRCAP-C in the ADP-bound state

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: chromatin organization
Cellular component: nucleus

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF17856
Domain description: TIP49 AAA-lid domain
Occurring in:
  1. RuvB-like 1
  2. RuvB-like 2
The deposited structure of PDB entry 8x1c contains 3 copies of Pfam domain PF17856 (TIP49 AAA-lid domain) in RuvB-like 1. Showing 1 copy in chain Q.
The deposited structure of PDB entry 8x1c contains 3 copies of Pfam domain PF17856 (TIP49 AAA-lid domain) in RuvB-like 2. Showing 1 copy in chain P.

PF06068
Domain description: TIP49 P-loop domain
Occurring in:
  1. RuvB-like 1
  2. RuvB-like 2
The deposited structure of PDB entry 8x1c contains 3 copies of Pfam domain PF06068 (TIP49 P-loop domain) in RuvB-like 1. Showing 1 copy in chain Q.
The deposited structure of PDB entry 8x1c contains 3 copies of Pfam domain PF06068 (TIP49 P-loop domain) in RuvB-like 2. Showing 1 copy in chain P.

PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H2A type 1-C
  2. Histone H2B type 1-C/E/F/G/I
  3. Histone H3.1
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1-C. Showing 1 copy in chain A.
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-C/E/F/G/I. Showing 1 copy in chain B.
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.1. Showing 1 copy in chain G.

PF00022
Domain description: Actin
Occurring in:
  1. Actin-related protein 6
  2. Actin, cytoplasmic 1
  3. Actin-like protein 6A
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF00022 (Actin) in Actin-related protein 6. Showing 1 copy in chain K.
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF00022 (Actin) in Actin, cytoplasmic 1. Showing 1 copy in chain S.
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF00022 (Actin) in Actin-like protein 6A. Showing 1 copy in chain T.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain D.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1-C
The deposited structure of PDB entry 8x1c contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1-C. Showing 1 copy in chain A.

PF03366
Domain description: YEATS family
Occurring in:
  1. YEATS domain-containing protein 4
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF03366 (YEATS family) in YEATS domain-containing protein 4. Showing 1 copy in chain W.

PF05499
Domain description: DNA methyltransferase 1-associated protein 1 (DMAP1)
Occurring in:
  1. DNA methyltransferase 1-associated protein 1
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF05499 (DNA methyltransferase 1-associated protein 1 (DMAP1)) in DNA methyltransferase 1-associated protein 1. Showing 1 copy in chain V.

PF16282
Domain description: SANT/Myb-like domain of DAMP1
Occurring in:
  1. DNA methyltransferase 1-associated protein 1
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF16282 (SANT/Myb-like domain of DAMP1) in DNA methyltransferase 1-associated protein 1. Showing 1 copy in chain V.

PF04438
Domain description: HIT zinc finger
Occurring in:
  1. Zinc finger HIT domain-containing protein 1
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF04438 (HIT zinc finger) in Zinc finger HIT domain-containing protein 1. Showing 1 copy in chain L.

PF08265
Domain description: YL1 nuclear protein C-terminal domain
Occurring in:
  1. Vacuolar protein sorting-associated protein 72 homolog
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF08265 (YL1 nuclear protein C-terminal domain) in Vacuolar protein sorting-associated protein 72 homolog. Showing 1 copy in chain J.

PF05764
Domain description: YL1 nuclear protein
Occurring in:
  1. Vacuolar protein sorting-associated protein 72 homolog
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF05764 (YL1 nuclear protein) in Vacuolar protein sorting-associated protein 72 homolog. Showing 1 copy in chain J.

PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Helicase SRCAP
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Helicase SRCAP. Showing 1 copy in chain I.

PF00176
Domain description: SNF2-related domain
Occurring in:
  1. Helicase SRCAP
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF00176 (SNF2-related domain) in Helicase SRCAP. Showing 1 copy in chain I.

PF07529
Domain description: HSA domain
Occurring in:
  1. Helicase SRCAP
The deposited structure of PDB entry 8x1c contains 1 copy of Pfam domain PF07529 (HSA domain) in Helicase SRCAP. Showing 1 copy in chain I.

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