› 8x1h

X-ray diffraction
2Å resolution

Crystal structure of N-terminal domain of Nucleocapsid protein of SARS-CoV-2

Released:
DOI: 10.2210/pdb8x1h/pdb
PDB entry 8x1h coloured by chain, front view.
PDB entry 8x1h coloured by chain, side view.
PDB entry 8x1h coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Unveiling potential inhibitors targeting the nucleocapsid protein of SARS-CoV-2: Structural insights into their binding sites.
Kumari S, Mistry H, Bihani SC, Mukherjee SP, Gupta GD
Int J Biol Macromol 273 133167 (2024)
PMID: 38885868

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145013 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 134 amino acids
Theoretical weight: 14.64 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC9 (Residues: 44-175; Coverage: 32%)
Gene name: N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: P212121
Unit cell:
a: 58.945Å b: 92.344Å c: 96.014Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.278
Expression system: Escherichia coli

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