› 8x5m

X-ray diffraction
2Å resolution

The Crystal Structure of JNK1 from Biortus.

Released:
DOI: 10.2210/pdb8x5m/pdb
PDB entry 8x5m coloured by chain, front view.
PDB entry 8x5m coloured by chain, side view.
PDB entry 8x5m coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang F, Cheng W, Yuan Z, Qi J, Li J

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 8 Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 41.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45983 (Residues: 2-364; Coverage: 85%)
  • Best match: P45983-3 (Residues: 2-364)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand Y4O 1 x Y4O
Ligand GOL 2 x GOL
Ligand EDO 1 x EDO
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2221
Unit cell:
a: 77.17Å b: 128.405Å c: 82.905Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.234
Expression system: Escherichia coli

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