› 8x5y

Electron Microscopy
3Å resolution

CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with astemizole

Released:
DOI: 10.2210/pdb8x5y/pdb
PDB entry 8x5y coloured by chain, front view.
PDB entry 8x5y coloured by chain, side view.
PDB entry 8x5y coloured by chain, top view.
Source organisms:
Primary publication:
Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor.
Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y
OpenAccess logo Nat Commun 15 84 (2024)
PMID: 38167898
Related structures: EMD-38075

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histamine H1 receptor; Soluble cytochrome b562 Chain: B
Molecule details ›
Chain: B
Length: 438 amino acids
Theoretical weight: 50.63 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35367 (Residues: 20-217, 257-258, 408-483; Coverage: 57%)
  • Canonical: P0ABE7 (Residues: 23-28, 31-65, 77-127; Coverage: 87%)
Gene names: HRH1, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand XB7 1 x XB7
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-38075
Expression system: Spodoptera frugiperda

Quick links

Citations

1 citations in other articles

Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor.
Xia et al. (2024)