› 8x81

Electron Microscopy
3.77Å resolution

Structure of leptin-LepR trimer with a large gap

Released:
DOI: 10.2210/pdb8x81/pdb
PDB entry 8x81 coloured by chain, front view.
PDB entry 8x81 coloured by chain, side view.
PDB entry 8x81 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural plasticity of human leptin binding to its receptor LepR
Xie YF, Li X, Qi J, Shang G, Lu D, Gao GF
Hlife 1 115-123 (2023)
Related structures: EMD-38132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214909 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Leptin receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 829 amino acids
Theoretical weight: 94.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48357 (Residues: 21-839; Coverage: 72%)
  • Best match: P48357-5 (Residues: 21-839)
Gene names: DB, LEPR, OBR
Sequence domains:
Leptin Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 167 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P41159 (Residues: 1-167; Coverage: 100%)
Gene names: LEP, OB, OBS
Sequence domains: Leptin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 19 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.77Å
Relevant EMDB volumes: EMD-38132
Expression system: Homo sapiens

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