› 8x8t

Solution NMR

NMR structure of p75NTR juxtamembrane domain in complex with RhoGDI N-terminal domain containing a phosphorylation-mimicking S34D mutation

Released:
DOI: 10.2210/pdb8x8t/pdb
PDB entry 8x8t coloured by chain, ensemble of 10 models, front view.
PDB entry 8x8t coloured by chain, ensemble of 10 models, side view.
PDB entry 8x8t coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75NTR to gate axon growth and neuron survival.
Ramanujan A, Li Z, Ma Y, Lin Z, Ibáñez CF
OpenAccess logo EMBO Rep 25 1490-1512 (2024)
PMID: 38253689

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139927 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rho GDP-dissociation inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52565 (Residues: 2-60; Coverage: 29%)
Gene names: ARHGDIA, GDIA1
Tumor necrosis factor receptor superfamily member 16 Chain: B
Molecule details ›
Chain: B
Length: 62 amino acids
Theoretical weight: 6.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08138 (Residues: 273-332; Coverage: 15%)
Gene names: NGFR, TNFRSF16

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 mention without citation

RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75NTR to gate axon growth and neuron survival.
Ramanujan et al. (2024)