8x96

Electron Microscopy
2.89Å resolution

Cryo-EM structure of enterovirus A71 A-particle in complex with Fab h1A6.2

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-268510 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 32.73 KDa
Source organism: Enterovirus A71
UniProt:
  • Canonical: A0A075QAW4 (Residues: 566-862; Coverage: 14%)
Sequence domains: Picornavirus coat protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 254 amino acids
Theoretical weight: 27.73 KDa
Source organism: Enterovirus A71
UniProt:
  • Canonical: A0A075QAW4 (Residues: 70-323; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-38166